Semisynthetic modification and Immunomodulatory activity studies of 19α-H lupeol esters

Isolation, semisynthetic modification of 19α-H lupeol to its various ester derivatives and their immunomodulatory activity studies has been envisage in this research work. 19α-H lupeol is a triterpenic alcohol which reacts with different acid chlorides or anhydride to give esters. Firstly, the acids are converted to their respective acid chloride derivative in the presence of thionyl chloride. 19α-H lupeol is then react with various acid chloride derivatives in the presence of dry pyridine to give different ester derivatives. The immunomodulatory activity of various ester derivatives was evaluated using Delayed type hypersensitivity (DTH) model. Cyclophosphamide was used as immunosuppressant. The different derivatives in the doses 15mg/kg and 30mg/kg produced minimum foot pad thickness as compared to control and CP. The derivatives also significantly reduced CP induced myelosuppression and thrombocytopenia.

Author(s): Anup K Chakraborty and Vinod D Rangari

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