Objectives: Renal stone is a common and a major cause of morbidity worldwide including Yemen. Therefore, this study was aimed to increase understanding of the prevalence and risk factors of renal stone in Hodeidah, Yemen and to identify of common medication used for its treatment because the lack of research done in this field in Yemen. Methods: A cross-sectional observational study conducted by recruiting case-series of adults and elderly who have renal stones within the age group from 18 to 85 years. 875 subjects received a simple explanation for the aim of the study an ethical issue. The subjects were allowed to complete a self-conducted screening questionnaire. The data were analyzed according to the Excel 2010 Software. Results: The results showed that renal stones were 27.31 %, renal salts were 39.65 %, and healthy subjects were 33.0 %. On the other hand, the renal stone and salt were found 70 % in male and 30 % in the female, relationship between the renal stone and age and sex of subjects was statistically significant (p < 0.05). Also, the common risk factors were the dehydration because the hot climate of Hodeidah as subtropical region and nutrition. In addition, 19 % of the subjects was treated pharmacologically, 26 % of the subjects was treated traditionally, 41 % combination and 14 % was treated surgically. Conclusion: The prevalence of renal stones is rising worldwide, namely in Hodeidah, Yemen, especially in men and with increasing age. Also, absence of health attention and education regarding renal dissolved agents used.