Coronary heart disease (CHD) is the main cause of disability and premature death worldwide. Angina and Heart attacks are the two most common aspects of CHD and it occurs due to the high cholesterol level. High blood cholesterol results in Atherosclerosis, which is characterized by presence of atheromas. Epidemiological studies have suggested a link between atherosclerosis and inflammation. In this study, we investigated the efficacy of antioxidant and hypolipidemic agents Tocotrienols and Black Caraway Oil (BCO) by analyzing all the parameters in plasma lipoprotein lipids, Total lipids, TC, TG, VLDL-C, LDLC, non-HDL-C, MDA, and in-vitro oxidizability of LDL as well as hepatic antioxidant enzymes (Catalase, Superoxide dismutase, Glutathione peroxidase and Glutathione reductase), as investigated in inflammation induced hyperlipidemic rats. All the plasma lipids parameters and hepatic antioxidant enzymes were significantly increased/decreased in hyperlipidemic control rats. After 4-week administration of Tocotrienols and BCO significantly restore the above altered parameters. In conclusion, Tocotrienols and BCO may be useful in the prevention and treatment of infection and inflammation induced hyperlipidemia, CHD and atherosclerosis.
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