Nuclear factor - kappa B (NF-ÃÂºB) consists of family transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation and survival. The transcription factor NF-ÃÂºB was discovered over 15 years ago, yet owing to its wide range of important cellular roles it remains an area of interest and current research. Discovered in the “B cell” white blood cell type, NF-ÃÂºB is the nuclear factor for the ÃÂº immunoglobin light chain in B cells. Since it was first observed, NF-ÃÂºB has been found to play an active role in inflammatory responses, cellular growth and apoptosis as well as being present in diseases such as cancer, arthritis, asthma, chronic inflammation, neurodegenerative diseases and heart diseases. The extensive involvement of Rel/NF-ÃÂºB transcription factors in human inflammation and disease establishes them as targets for therapeutics. There are over 800 compounds that have been shown to inhibit NF-ÃÂºB signaling and thus, the physiological or the pharmacological utility of using any single compound for inhibition of NF-ÃÂºB acting is a bit muddled. Nevertheless, knowledge of the molecular details of the pathway is enabling the development of more specific and potent inhibitors of NF-ÃÂºB signaling, and indeed, some NF-ÃÂºB signaling inhibitors are entering clinical trials.
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