Physico-chemical characterization of acrylate pseudolatex films and in-vitro release profile of ketorolac tromethamine from the films

The present study was undertaken to develop acrylic transdermal film of ketorolac tromethamine from aqueous pseudolatex by using polymeric combination of Eudragit L-100 and Eudragit S-100 by solvent evaporation method. Physicochemical characterization of the prepared pseudolatex films is done for the drug content, thickness of the film, weight variation, moisture content, moisture uptake, and water vapor transmission, folding endurance and scanning electron microscopic study. The in-vitro release of drug from the pseudolatex films was carried out by using 6 stage dissolution test apparatus rotating paddle type (USP-II) and the effect of two polymers in different ratio in the pseudolatex film on the release of the drug has been studied. The drug-polymers compatibility study was done by Fourier Transform Infrared Spectroscopy (FTIR) and the surface morphology, the distribution of drug in the films was studied by Scanning Electron Microscope (SEM). The polymers used in the films were found compatible by FTIR study and the drug is found uniformly distributed (SEM study) to give dosage uniformity per unit area of the films. The results of physicochemical properties revealed that the pseudolatex films of ketorolac trometamine using Eudragit L-100 and Eudragit S-100 will be sufficiently stable and suitable for transdermal application. The results of in-vitro release profile ascertained that the release rate can be retarded to get controlled release characteristics of the formulation by incorporating higher proportion of EL-100 polymer in the films.

Author(s): Pintu K De and Koustab Biswas

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