The roots and stem bark of Ceiba pentandra and Anogeissus leiocarpus was subjected to hot Soxhlet extraction using solvent of different polarity, hexane, ethyl acetate, acetone, methanol and water. The methanol extracts gave the highest yield of 17.5% highest polar solvent while hexane being the lowest polar solvent gave the least percentage recovery of 1.12%. The colour and texture of each of the extract was also determined. Hexane and ethyl acetate extract showed yellow and orange colour, with the texture oily and solid. While acetone, methanol and water extracts gave brown and dark brown colour with the texture being solid and pastry. The acute toxicity of the extracts was also determined by using both the oral and interperitoneally dosage concentration. The interperitoneally dosage with slight modification tends to be toxic than the oral dosage.