One Pot Three Component Synthesis of 2,4,5-triaryl-1H-imidazole Using PEG-400 and their Antibacterial Screening

2,4,5-triarylimidazoles could be obtained in excellent yields by one-pot three component condensation of benzil, aromatic aldehydes and ammonium acetate in presence of polyethylene glycol PEG-400 as medium and catalyst. The synthesis highlights a comparative study of conventional and ultrasound methods. The compound 4c was investigated in vitro against Gram +ve and Gram –ve bacteria at different concentrations and compared with standard drug ciprofloxacin.

Author(s): Chandrashekhar G Devkate, Khandu D Warad, Mahendra B Bhalerao, Digambar D Gaikwad and Mohammad Idrees M Siddique

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