A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the unsubstituted N1 of these indolyl pyrazoline was found to give better activity than other N1- sustituted indolyl pyrazolines. The reference drug for the inflammatory activity was Indomethacine.