Reach Us +44-1764-910199

Abstract

Newer Substituted Indolyl-Pyrazoline Derivatives as Anti-Inflammatory Agents

A novel series of nine indolyl pyrazoline pharmacophore were synthesized by the reaction of hydrazine hydrate derivatives with the synthesized chalcones (C4,C5,C6). The chalcones were synthesized by the Claisen Schimdt condensation method. These pyrazoline derivatives were evaluated for anti-inflammatory activity using Carrageenan induced paw oedema method. The activity profile reveals that the unsubstituted N1 of these indolyl pyrazoline was found to give better activity than other N1- sustituted indolyl pyrazolines. The reference drug for the inflammatory activity was Indomethacine.


Author(s): Minakshi Shroff and Daharwal SJ

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Abstracted/Indexed in
  • Chemical Abstracts Service (CAS)
  • Google Scholar
  • Genamics JournalSeek
  • Academic Keys
  • ResearchBible
  • The Global Impact Factor (GIF)
  • International Society of Universal Research in Sciences
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • Scientific Journal Impact Factor
  • Jour Informatics
  • International Committee of Medical Journal Editors (ICMJE)
  • CiteSeerx
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs