Microwave assisted Synthesis and Evaluation of Novel 3-methyl-1,4- dihydropyrazol-5-one derivatives as Anti-inflammatory agents

Derivatives of 3-methyl-1,4-dihydropyrazol-5-one(1a), 3-methyl-1-phenyl-1,4-dihydropyrazol-5-one(1b) and 3- methyl-1-(2,4 dinitrophenyl)-1,4-dihydropyrazol-5-one(1c) were synthesized by condensation reactions from Ethylacetoacetate with different Hydrazides then these were subjected to Mannich reaction with organic acids in presence of Formaldehyde to produce different derivatives of Pyrazolone. Novel nine compounds were characterized by IR, 1H NMR 13C-NMR, MS and CHN analysis. Evaluation of Anti-inflammatory activity was carried out on all synthesized the compounds. Out of A1-A3, B1-B3 and C1-C3 compound A1, B2 and C1 found to have potent Anti-inflammatory activity compare to standard Diclofenac Sodium

Author(s): Ramesh S Kalkotwar1, R. B. Saudagar2 and D. A. Jain3

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