L-Tyrosine Catalysed Mild and Efficient Synthesis of Dihydropyrano[2,3c] pyrazole under Microwave Irradiation

A highly efficient and environmentally benign protocol has been developed for the construction of dihydropyrano[2,3-c] pyrazole derivatives through one-pot, multi-component cascade reaction of various aldehydes, acetoacetic ester, hydrazine hydrate and malononitrile under microwave irradiation using L-Tyrosine as catalyst in the presence of green solvent medium (ethanol-water) is described. The significant feature of this protocol is the use of ethanol-water as a green solvent system.

Author(s): Balaji D Rupnar, Vijay P Pagore, Sunil U Tekale, Suresh U Shisodia, Rajendra P Pawar

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