Hepatoprotective effect of standardized antioxidant phenolic fractions of Hibiscus mutabilis Linn.

Defatted polar phenolic fraction of Hibiscus mutabilis Linn. from leaf, stem and flowers was evaluated against carbon tetrachloride induced hepatic injuries in rats. In this test, markers of liver injuries (ALT, AST, ALP) were measured analytically after treatments confirmed by histophatological consideration in rat livers. These fractions were standardized by HPTLC quantitatively and evaluated for antioxidant potential using DPPH and nitric oxide models. Administration of carbon tetrachloride significantly increased the release of ALT, ALP and AST. Treatment of rats with ethanol fractions significantly modulate these enzymes in blood serum to normal values. Also, histopathological analysis of liver biopsies and antioxidant potential of standardized fractions was consistent with the biochemical findings. Experimental work led to conclude the curative potential of defatted antioxidant ethanolic fractions of H. mutabilis leaf, stem and flower against chemical (carbon tetrachloride) induced hepatic injuries.

Author(s): Dipak N. Raut

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