Hepatoprotective activity of a polyherbal mixture in ferrous sulphate and ethanol induced hepatotoxicity experimental animals

Protective effect of a polyherbal mixture was evaluated for their hepatoprotective activity against ferrous sulphate and ethanol intoxication. Biochemical estimations for AST, ALT, ALP, Total bilirubin and Total protein were carried out at the end of treatment schedule for respective models. The mixture of equivalent amounts the extracts of Picrorhiza kurrao, Embilica officinalis, Andrographis paniculata, Eclipta alba to constitute total doses T50 mg was prepared. The hepatoprotective effects polyherbal mixture were estimated by liver function test and serum profile. The results revealed that polyherbal mixture produced significant hepatoprotective effect by decreasing serum transaminase like AST, ALT, ALP (alkaline phosphatase) and total bilirubin, but also significantly increased the levels of total protein. Morphological parameter like liver weight was restored by the polyherbal mixture. The effects of polyherbal mixture were comparable with standard drug silymarin.

Author(s): Nilima. S. Pawar, Vikram.V. Nimbalkar, Pandurang. M. Gaikwad

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