Growth and characterization of drug crystals from sodium meta silicate

An Active Pharmaceutical Ingredient (API) Aspirin was crystallized from Sodium Meta silicate (SMS) by gel growth method for the first time. The growth parameters and the various properties of the drug crystals are observed and characterized by different instruments. The lattice parameters were determined by single crystal X-ray diffraction studies. FTIR and UV - Vis spectral studies have also been carried out to identify the functional groups present and the rate of absorbance of the drug crystal. Thermal analysis by TG-DTA shows good thermal stability. Dielectric studies reveal that the dielectric constant decreases with increase in frequency

Author(s): Bhavani K and Sankaranarayanan K

Abstract | PDF

Share This Article