Gold Nanoshell: The Advancing Nanotechnology to Fight Against Cancer

It has been almost 40 years since the “cancer war” had been declared. It is now generally believed that personalized medicine is the future for cancer patient management. Gold nanoparticles, nanospheres, nanorods, nanoshells will be discussed in detail regarding their uses in in–vitro assays, ex–vivo and in–vivo imaging, cancer therapy and drug delivery. Multifunctionality is the key feature of nanoparticle–based agents. Targeting ligands, imaging labels, therapeutic drugs, and other functionalities can all be integrated to allow for targeted molecular imaging and molecular therapy of cancer. Gold nanoshells, mainly composed of the silica and gold metal. The antibodies of Anti–Epidermal Growth Factor Receptor is chief component of Gold Nanoshells therapy used to target the cancer cells and to “guide” the Gold nanoshells to detect the cancer cells visually by microscope. The future looks brighter than every at many hurdles remain to be conquered. A multifunctional platform based on gold nanoparticles, with multiple receptor retargeting, multimodality imaging and multiple therapeutic entities, holds the promise for a “magic gold bullet” against cancer. In this review, we will summarize the current state–of–the–art of gold nanoshells with mechanism in biomedical applications targeting cancer.

Author(s): Dron P Modi, Sunita Chaudhary, Ragin Shah and Dhrubo Jyoti Sen

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