Gastroprotective and antioxidant activities of Ceropegia juncea leafethanol extract

The present study was aimed to evaluate gastroprotective and antioxidant activities of ethanolic extract of Ceropegia juncea (L.) Taub in rats. Effect of various doses (100, 200, 300 and 400 mg/kg p.o.) of Ceropegia juncea leaf ethanolic extract (CJEE) were studied in pylorus-ligation and ethanol-induced gastric mucosal injury in rat. The effect of CJEE on free radical induced lipid peroxidation determined by malondialdehyde estimation method. Amount of antioxidant enzymes (viz. superoxide dismutase (SOD), Catalase (CAT), reduced glutathion (GSH)) along with various membrane bound enzymes in tissue homogenate was also determined using previously described methods. Treatment with CJEE showed significant reduction in ulcer index (P<0.01) in both the models along with the reduction in volume and total acidity, and an increase in gastric juice pH. The animals treated with different doses of CJEE showed an increase in the levels of SOD, CAT, GSH and membrane bound enzymes like Ca2+ ATpase, Mg2+ ATpase, Na2+ ATpase and decrease in lipid peroxidation in both the models suggest its antioxidant activity of CJEE. These effects of CJEE suggest its gastroprotective activity, which can be attributed to its antioxidant properties. Further, the polypenolics of the plant may be held responsible for these effects, which has been found active against various ulcerogenic agents in previous reports.

Author(s): Sharma Paras, Mehta S.C., Dubey Gargee, Lakshmayya B., Kaushik Sunil

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