Formulation of viburnum coriaceum arista and determination of its anticonvulsant activity in mice

The leaves,stems and roots of Viburnum coriaceum were collected from Nilgiri hills, Tamil Nadu, India. A primary organic analysis on the species revealed the presence of bio-active molecules such as tannins, saponins, phenolic compounds (flavonoids) and other phenolic glycosides as their principal phyto- constituents. The crude drug (Patha) was formulated in to an arista using conventional anaerobic fermentation process for about 90 days. The prevention of seizures induced by MES in laboratory animals is the most commonly used preliminary screening test for characterizing potential anticonvulsant drugs. The MES test is considered to be a predicator of likely therapeutic efficacy against generalized tonic-clonic seizures.The present study revealed that the Viburnum arista blocked tonic seizures induced by MES significantly (p<0.001) at the dose 200, 400 and 600mg/kg. b.wt. (p.o).

Author(s): K Prabhu and K Ponnudurai

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