Formulation Development and In Vitro Evaluation of Mucoadhesive Buccal tablet Containing Mucolytic Agent

The mucoadhesive buccal tablets with drug Bromhexine Hydrochloride was formulated by employing diverse ratios of excipients and using direct compression method. The polymers like Carbopol 934 p, Pectin, Sodium alignate, HPMC km4 and excipients like Mannitol, Microcrystalline cellulose, Magnesium stearate, and Talc were used in preparation of formulations. The formulated mucoadhesive buccal tablets were assessed for quality attributes like weight variation, hardness, thickness, friability, drug content, moisture absorption, surface pH, swelling index, in vitro drug release studies, and stability studies. Among the various formulations studied formulations F5, F10 and F15 demonstrated comparatively better results. On analyzing regression co efficient values of the optimized batches, it was found that formulations F5, F10, and F15 exhibit Higuchi’s release kinetic. The data was fitted into the Korsemeyer- Peppas equation which specifies a coupling of diffusion and erosion mechanism for release of drug. Based on the study results it is concluded that development of mucoadhesive buccal tablets of bromhexine hydrochloride is one of the alternative route of administration to avoid first-pass metabolism and to improve the bioavailability of the drug through buccal mucosa and to improve the release of drug for extensive period of time. In addition, these formulations also reduce the need of frequent administration thereby enhancing the patient compliance. Findings provide evidence that these formulations have a strong prospective as buccal drug delivery system. However, further studies are essential to understand the in vivo performance and permeation aspect of the formulations to finalize the robust formulation.

Author(s): Nagarajan, Gopinath.S,G.V. Peter Christoper,Preethy Ani Jose

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