Formulation development and evaluation of taste masked Cefuroxime axetil dry suspension

Cefuroxime axetil is an oral antibacterial prodrug of cephalosporin antibiotic, cefuroxime. It is used frequently for pediatric conditions like upper respiratory tract infections. The bitter taste of Cefuroxime axetil greatly hinders the further development of suitable formulations of this drug for oral use. Hence, it is important to mask the bitter taste and also to make them suitable for oral use. Lubritab is used as a taste masking agent. The taste masked dry suspension was made by compaction process. The prepared suspension was evaluated for various parameters like sedimentation volume, degree of flocculation, drug content and In-vitro dissolution profile. All the parameters were found to be within limits. When the results were also compared with marketed formulation, the prepared suspension was found to be better with respect to marketed preparation.
Author(s): J. Vinod and A. Chenthilnathan

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