Formulation development and evaluation of oral floating insitu gel of Ilaprazole

The development of in situ gel systems has received considerable attention over the past few years. In the past few years, increasing number of in situ gel forming systems have been investigated and many patents for their use in various biomedical applications including drug delivery have been reported. In the present research work Oral Floating Gel of Ilaprazole was formulated using Sodium Alginate, HPMC K100M, Eudragir RSPO, Ethyl cellulose, Rosin. In the optimized batch Sodium Alginate 2% and Ethyl cellulose 2% (1:1) ratio gave gastric retention of drug Ilaprazole for 12 hours. Invivo study was performed by providing the formulation to rabbit and then X-ray were taken for the confirmation of formation of gel in stomach and floating of dosage form for 12 hrs. And it was found to be floating for 12 hrs. From formulation and evaluation studies of oral floating insitu gel it was observed that gas forming agent sodium bicarbonate and calcium carbonate 2% each (1:1) proportion gives floating of gel for >12 hrs.

Author(s): Archana D. Kajale* and A. V. Chandewar

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