The work was aimed to persuade the effect of size of sugar spheres and compression parameters on the prepared tablets, containing enteric coated pellets of omeprazole. Multiple unit dosage forms of Omeprazole were formulated by wurster process. The sugar spheres (#18/20, #20/25, # 30/35, #40/60) were coated with the drug, HPMC 5cps, Eudragit L30D55 and then with PEG. The pellets were compressed into tablets using Prosolv granules as a pressure absorbing matrix. The compressed tablets were characterized for DSC, SEM, and XRD. The Optimized formulations showed plastic deformation and the pellets embedded in the tablet maintain their integrity with no considerable change in their surface properties. In vitro release profile of formulation F8 containing sugar spheres (#40/60) coated with, Eudragit L30D55 70% w/w and PEG 4000 20% w/w as cushioning agent showed release up to 97% at the end of 1 hr in buffer. The DSC, X-RD results proves that there is no potent incompatibility between the drug and the polymer. The higher the size of sugar spheres higher will be the smash up to the coating and less resistance to gastric environment than the small spheres. Small pellets were best suited for compression of multiple unit particulate systems of Omeprazole.
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