Formulation and in vitro evaluation of alginate-tamarind kernel polysaccharide microparticles

Felodipine alginate TKP microparticles were developed using sodium alginate and tamarind kernel polysaccharide (TKP) by ionic gelation technique using 5-level, 2-factor central composite experimental design. The concentration of sodium alginate (X₁) and concentration of calcium chloride (X₂) were selected as independent variables. % production yields (Y₁), % entrapment efficiency (Y₂) and % mucoadhesion strength (Y₃) were taken as response variables. Evaluation of microparticles was carried out in terms of shape, size, entrapment efficiency (EE), In vitro release, Scanning electron microscopy (SEM), and stability studies. The results revealed that concentration of alginate and calcium chloride had a significant synergistic effect on % entrapment efficiency and mucoadhesion strength.

Author(s): Bharati S. Patil, Hitendra S. Mahajanand Sanjay J. Surana

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