Formulation and Evaluation of Nystatin Vaginal Tablet

The objective is to formulate vaginal tablet of Nystatin and evaluate the in vitro antimycotic effectiveness against the marketed product in Candida albicans. Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei. Vaginal tablet of Nystatin were formulated with 100,000 Units of Nystatin. The tablets were made with Ethyl Cellulose, 4 cps as polymer, Pregelatinized Starch (Starch 1500) as binder, PEG 8000 as wetting agent, Co-processed mixture of Lactose–Microcrystalline Cellulose (Cellactose) as diluent and Stearic Acid (Stellipress 1200 Poudre) as lubricant. The optimized formulation was subjected to stability studies at accelerated condition. Test and marketed formulations were evaluated for appearance, weight variation, thickness, hardness, friability, drug content and in vitro drug release. In vitro studies on anti mycotic evaluation were carried out for the optimized formulation in three sets of medium cultured with Candida albicans and the zone of inhibition were compared with the marketed one.

Author(s): Packiaraj JM*, Venkateswaran CS, Mohamed PS, Janakiraman K

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