Formulation and evaluation of in-situ gel of bromhexine hydrochloride for nasal delivery

The aim of the present study was to minimize the unwanted toxic effects of Bromhexine hydrochloride (BHC) by kinetic control of drug release. BHC was incorporated into the, blends of bio compatible, bio polymers such as Poloxamer (PLX) and Hydroxy Propyl Methyl Cellulose (HPMC) in the form of in situ gel by cold technique to reduce muco ciliary clearance by using mucoadhesive polymer in gel, thereby, increasing the contact of formulation with nasal mucosa and hence improving the absorption of drug. The results revealed that increased bio adhesive polymer HPMC concentration, decrease the gelation temperature( T1) and gel melting temperature (T2). pH of all the formulations were found to be within the range between 6.9- 7.5 ,and the nasal mucosa can tolerate the pH of the above solutions. The drug content for all the prepared formulations was found to be in the range of 96%- 100%. The result of mucoadhesion test indicate that the level of HPMC increases, the mucoadhesive strength also increases. The developed formulations had optimum viscosity required for convenience in application at the site. With increase in the concentration of HPMC increase in viscosity was observed and influences diffusion of drug particles. The optimized formulations shows the controlled drug release (85.12%) than aqueous drug solution(92.32%). From the in vitro permeation study viscosity of the formulation is increased and release of the incorporated drug can be prolonged. The drug release performance was greatly effected by bio polymers used and their compositions in the in situ gels preparation, which allows absorption in nasal mucosa.

Author(s): M. Vijay Kumar, Aravindram A. S, Rohitash K, D. V. Gowda, Parjanya K

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