Formulation and Evaluation of Floating Multiparticulate Drug Delivery System of Glipizide

Gastroretentive floating multiple-unit drug delivery system for glipizide as a model drug was developed for prolongation of gastric residence time. Floating microspheres were prepared by ionotropic gelation method using polymeric material such as chitosan. D-optimal design was utilized to investigate the joint influence of two variables: drug to polymer ratio (X1) and concentration of effervescent agent (X2) on the drug entrapment efficiency, percentage buoyancy, and cumulative percentage drug release. Particle size and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy respectively. Formulated microspheres exhibited prolonged drug release and remained buoyant for more than 12 h.
Author(s): Rakesh Pahwa, Neeta, Seema, Rajeev Garg and Sanju Nanda

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