Formulation and characterization of fast dissolving tablet of domperidone

Fast dissolving drug delivery system (FDDDS) is suited for the drugs which undergo high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to mouth plasma peak levels, which in turn minimize adverse/side effects. Some drugs are absorbed well from the mouth, pharynx and esophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient's saliva along with the soluble and insoluble excipients. The sublingual and buccal delivery of a drug via oral tablet has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile of the medicament.

Author(s): Navneet Kumar Verma, Shivendra Pratap Singh, Abhay Pratap Singh, Praveen Kumar Rai and Reena Singh

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