Pomelo or shaddock (Citrus maxima) is a widely cultivated and consumed citrus variety in India. In the present study, the methanol extract of Citrus maxima (J. Burm.) Merr. leaves (MECM) was evaluated for its in vivo antioxidant and hepatoprotective activity against paracetamol induced hepatotoxicity in Wistar albino rats. The results of the present study established the hepatoprotective and antioxidant activity of MECM at the dose levels of 200 and 400 mg kg-1 body weight and showed dose dependent decrease in the bilirubin, total protein and serum hepatic enzyme levels in comparison to the paracetamol control rats. By MECM treatment, the hepatic TBARS levels were decreased and GSH and catalase levels were increased as comparable to the silymarin treated group (25 mg kg-1 b.w.) which served as reference. The data were supplemented by histopathological studies of the rat liver sections.