Enhanced solubility and dissolution rate of Olmesartan medoxomil using crystallo-co-agglomeration technique

Olmesartan medoxomil is a novel antihypertensive drug having low aqueous solubility and poor micromeritic properties. Therefore the crystallo-co-agglomeration of olmesartan have been attempted to improve its physicochemical and micromeritic characteristics. The effect of different polymers such as poly-vinyl pyrollidone (PVPK30), and hydroxypropyl- β- cyclodextrin (HPβCD) on solubility, dissolution rate and flowability of olmesartan medoxomil was studied by crystallo-co-agglomeration technique. The agglomerates were characterized by X-ray powder diffractometry (XRPD), Scanning electronic microscopy (SEM) and Fourier transformationinfrared spectroscopy (FTIR). It was found that saturation solubility, micromeritic properties and dissolution characteristics of agglomerates were significantly improved than that of pure olmesartan medoxomil. Hence it could be concluded that crystallo-co-agglomeration could be one of the effective approaches for improved performance of olmesartan medoxomil.

Author(s): Ashwini A. Yadav, Dhanashri S. Yadav, Poonam S. Karekar, Yogesh V. Pore, Pankaj Gajare

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