Effects of variables on degradation of folic acid

Folic acid, a member of vitamin B group is used in many medical disorders. The study aimed at investigating the onset and extent of degradation of folic acid from treatments of acids, alkailis and ultraviolet (UV) radiations. Solutions of folic acid were prepared in dilute acid (0.1N HCl) and alkali (0.1N NaOH) as well as powdered folic acid placed under UV light. The three treatments were allowed for 5 hrs. The results showed that acidic solution (pH 4.2) has faster onset and highest extent of degradation followed by UV then alkali treatment. All the variables have effects on folic acid degradation, hence the need to take precaution of storage condition of folic acid tablets and powders as well as ingredients to be used in formulation or compounding folic acid syrup.

Author(s): S. Yakubu and J. Muazu

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