Effectiveness of Sodium CMC as a Polymer for the Development of Transdermal Patches Containing Paracetamol IP in Paediatric Category

Paracetamol IP traditionally considered as a NSAID, is an effective analgesic and antipyretic drug available as over the counter without prescription. Paracetamol IP is used widely in all age groups and it has intensely bitter taste which makes it difficult to administer in children. The current study is an attempt to develop transdermal patches of Paracetamol IP for paediatric patients by solvent evaporation method (with slight modifications) using a hydrophilic polymer, Na CMC in combination with polyvinyl pyrrolidone and glycerin as plasticizer. To improve the effective permeation of Paracetamol IP through skin, permeation enhancers such as 5% of oleic acid, menthol and ethanol are incorporated. All the developed transdermal patches showed desired properties of an ideal TDDS and followed ideal zero order kinetics. Formulation containing 5% menthol as permeation enhancer showed higher release rates.

Author(s): Sarath chandran C, Vipin KV, Ann Rose Augusthy, Shahin Muhammed TK, and Sabna N.S

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