Effect of Various Polymers on Carvedilol Transdermal Films: Invitro Permeation Studies

Transdermal films of carvedilol were prepared by the solvent evaporation technique with combination of different polymers such as EC: PVP K-30, EC: HPMC K-15M, EC: Carbopol-934. During the optimization of various formulations, polymer ratios of 6:4 and 8:2 amongst the all combinations of various polymers ratio were taking into consideration to develop and evaluation of tansdermal films. It was optimized on the basis of film’s uniformity, folding endurance and transparency. Total six formulations were selected (A-1 to A-6) for further evaluation. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. In vitro permeation studies were performed using a Franz diffusion cell across hairless albino rat skin. On the basis of physicochemical evaluations and In-vitro drug permeation study, A-3 and A-5 were chosen as the best films and among the both preparation, only A-5 was found to have maximum permeation, maximum steady state flux and maximum permeability coefficient and kinetic model proved that permeation of drug was followed the first order rate. The patches were seemingly free of potentially hazardous skin irritation. In-vitro drug permeation study, the percent of drug permeated was found to maximum 95.44 and 90.12% from A-3 and A-5 film respectively. Based on physicochemical and in-vitro release experiments, A-3 and A5 chosen as the best films among both only A-5 was found to have maximum release, maximum steady state flux and maximum permeability coefficient.

Author(s): Bankim C Nandy , Sanjay K Chourasiya, Sandipan Roy, Bhaskar Mazumder, Kailash C Meena,Dharmedra Aujha, Manju Makhija, Kadambari Pathak

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