Different Drugs are Tried to Counteract the Cardio Toxicity of Doxorubicin and their Suggested Mechanisms: A Review Article

Doxorubicin remains an important drug of chemotherapeutic agents. Unfortunately, its efficacy in treating in different types of cancer cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart problems and cardiomyopathy. It is very critical to understand the mechanism of doxorubicin induced cardiotoxicity to counteract this problem. Oxidative stress, apoptosis, autophagy and senescence are the most important causes for its cardiotoxicity, therefore, different drugs like melatonin, metformine, captopril, rosuvasatatin and omega-3 can be considered feasible candidates to protect against its cardiotoxicity. Therefore, the mechanisms of its cardiotoxicity as well as different drugs used to counteract it are discussed in this review.

Author(s): Ibrahim El-Sayed

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