Development and validation of simultaneous equation method for estimation of ebastine and montelukast sodium in combined tablet dosage form

Simultaneous Equation Method for simultaneous estimation of Ebastine and Montelukast sodium in combined tablet dosage form has been developed. The UV spectrophotometric method is the Simultaneous Equation method, which involves the formation of absorbance equation at 253.00 nm maximum absorption of Ebastine and at 344.00 nm the maximum absorption of Montelukast Sodium.The linearity ranges for Ebastine and Montelukast Sodium were 5-45 μg/ml and 5-45 μg/ml respectively. The accuracy of the method was assessed by recovery studies was found to be and 100.43 ± 0.1893 and 100.22 ± 0.3215 for Simultaneous Equation method for Ebastine and Montelukast Sodium respectively. Developed method is simple, accurate and rapid; require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories

Author(s): Jyoti J. Savsani, Pratik P. Goti, Parula B. Patel

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