Development and validation of analytical method for naproxen and pantoprazole in capsule dosage form

A simple sensitive and precise high performance liquid chromatographic method for the analysis of naproxen and pantoprazole has been validated and used for the developed, validated and used for the determination of compound in commercial pharmaceutical products. The compound were well separated on a on hypersil BDS C-18,250×4mm,5μg reversed phase column by use of a mobile phase consisting of mixed phosphate buffers (K2HPO4,KH2PO4)(PH:6.5) Acetonitrile (55:45 v/v ) at a few rate of 1.0ml min-1 with detection wavelength at 290nm.the linearity range were 5 to 30μg/ml for naproxen and 0.4-2.4μg/ml for pantoprazole the recovery amount was more than 99%the high suitability of the method for determination of naproxen and pantaprozole in pharmaceutical dose form.

Author(s): S. Mohideen, M. Shivakanth, P. SureshKumar, S. Navaneetha Krishnan, Y. Surendranath and T. Satyanarayana

Abstract | PDF

Share This Article