Design, synthesis and pharmacological screening of 1-acetyl-3-aryl-5-(4-methoxyphenyl)pyrazoles as a potential anti-inflammatory agents

4-methoxybenzaldehyde was react with various aromatic ketones by using alkali as catalyst to afford (E)-3-(4-methoxyphenyl)-1-aryl-prop-2-en-1-ones (2a-j). Compounds (2a-j) on reaction with hydrazine hydrate in the presence of glacial acetic acid to gives 1-Acetyl-3-aryl-5-(4- methoxyphenyl)pyrazoles (3a-j). The obtained compounds were evaluated for their antiinflammatory activites as well as gastric ulcerogenic effects. Results showed that 3i and 3j showed potent anti-inflammatory activity in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with etoricoxib.

Author(s): Kapupara Pankaj P, Suhagia Bhanubhai N, Bhandari Anil and Jivani N P

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