Comparative study of cardiac action in infected and non-infected leaves of Ocimum tenuiflorum

Ocimum tenuiflorum had many traditional uses reported and it is widely available. Asperigillus Niger fermentation is "generally regarded as safe" (GRAS) by the United States Food and Drug Administration. In the present study leaves of Ocimum tenuiflorum infected with Asperigillus niger were used to produce positive ionotropic and chronotropic effects in frog’s heart whereas only positive ionotropic effect was reported in normal leaves. This is due to biotransformation which is confirmed from preliminary phytochemical tests. This study concludes after infection of normal leaves shows the presence of steroids and amino acids might be reason for activity.

Author(s): E. Tamiljothi, Rameez Reza, P. V. Surya Lakshmi, R. Karthikeyan and P. Srinivasababu

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