Cannabinoid Dronabinol alkaloid with antimicrobial activity from Cassia alata Linn

Chemical investigation of the bioactive constituents from the seeds of Cassia alata Linn. (ringworm plant) resulted in the isolation of a new cannabinoid alkaloid (4-butylamine 10- methyl-6-hydroxy cannabinoid dronabinol). The structure was elucidated using NMR spectroscopy in combination with IR and MS spectral data. Antimicrobial studies showed that the isolated compound successfully inhibited Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus Candida albicans and Aspergillus niger. The antimicrobial observation of the above compound against these pathogens showed that the bioactive compound could be responsible for the activity of C. alata and its use in herbal medicine in Nigeria

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