Biological screening of Avicennia marina for anticancer activity

Avicenniaceae family is a member of true mangrove plants which has one genus, 11 species and several subspecies. Avicennia marina is the most current species among these plants in many forests. Regarding to the presence of many active biological constituents in this plant and their applications in traditional and alternative medicine, the in-vitro anticancer activity of its leaf extract on various cancer cell lines (HL-60, HepG2, NCI-H23 & HEK-293T) were determined by MTT bioassay. With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic and aqueous extract of Avicennia marina shown cytotoxicity against HL-60 and NCI-H23 cell line with efficient IC50 values and shown negligible toxicity against normal cell line (HEK-293T).
Author(s): Prakash S. Sukhramani, Piyush M. Patel

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