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Anti-ulcer potential and toxicological evaluation of two siddha formulations

The two Siddha formulations, Nillavari Choornam and Thamarai Parpam were investigated for anti-ulcer activity and their toxicological effects in rats. Nilaavari Choornam and Thamarai Parpam are procured from the Indian Medical Practitioners Cooperative Pharmacy and Stores Limited, Thiruvanmiyur, Madras-41 (IMPCOPS 1989). Nilaavari Choornam and Thamarai Parpam were investigated at the dose levels of 200mg/kg and 250 mg/kg body weight respectively. The methods of pylorus ligation induced ulcer model, aspirin induced ulcer model and gastric lesions induced by stress in rats were used to investigate the anti-ulcer activity and to evaluate their possible mechanism of action. The toxicological effects of the two Siddha formulations were studied at the dose levels of 100, 200, 400,800 and 1000 mg/kg body weight of the animals. Both, Nilaavari Choornam and Thamarai Parpam were found to posses significant anti-ulcer activity in all the above models. The possible mode of action might be by antisecretary effect and neutralization of acids. Also it was found that even at the higher dose levels of 1000mg/kg body weight the two preparations were devoid of any significant toxic effects. Thus it can be concluded that the two Siddha formulations, Nilaavari Choornam and Thamarai Parpam posses significant anti-ulcer activity and have no toxic effects unless given continuously at higher dose levels.

Author(s): Manjunath C, Elango K, Chandra Prakash K

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