Abstract
Anti-proliferation and molecular docking study of s-triazinyl uracil hybrids
A series of uracil substituted s-triazinyl derivatives (U1T, U2T & U3T) were synthesized. All the hybrids were in vitro evaluated for their anti-proliferative activity in human cancer cell lines, namely HepG2 hepatocellular carcinoma and normal hepatocytes. Docking studies have been performed with suitable enzyme to study the mode of action. The IC50 values of these compounds showed less viability exhibited in tumor cells compare to normal cells. The hybrid molecules distinguish between cancer cell from normal cell and reducing the toxicity. Finally, a theoretical kinetic study was established to predict the ADME of the active hybrids. These compounds are worthy of further evaluation as anticancer agents.
Author(s): M. Karthick, M. Shanmugam and V. Chidambaranathan
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