Anti-inflammatory and antinociceptive activity of hydroethanolic extract of Woodfordia fruticosa Kurz flowers

In the present study, the analgesic and anti-inflammatory activity of 95% ethanolic extract of Woodfordia fruticosa (WFE) flowers in acute, subacute and chronic models of inflammation was assessed in rats and mice. Oral administration of WFE (250 and 500 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin and autocoids induced hind paw edema), subcute (formaldehyde-induced hind paw edema) and chronic (cotton pellet granuloma) models of inflammation. WFE at a dose level of 250 and 500 mg/kg exhibited a significant (P < 0.05) reduction in writhes induced by intraperitoneal administration of acetic acid in mice. The hot plate reaction time was increased at a dose of 250 and 500 mg/kg significantly (P < 0.05).

Author(s): Neeraj Verma, G. Amresh, P. K. Sahu, Neelam Mishra, Ch. V. Rao, Anil Pratap Singh

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