Ameliorative Effect of Curcumin against Excitotoxin induced brain damage in rats

Curcumin (curcuma longa linn), the major constituent of turmeric is been used in food preparation as well as to treat inflammatory disorders. Excitotoxins, the ultimate brain layer, that have a bland taste, which stimulate the neuron brain cells and lead to exhaustion. The present study examined the ability of this compound to protect against neuronal brain damage of rats. The biochemical changes resulting from curcumin also correlated well with its ability to ameliorate the changes induced by excitotoxin. The beneficial effects of curcumin appear as a promising class of compounds for brain protection. The mitochondrial enzymes and histopathologiocal examination was carried out to measure the damage induced by excitotoxin. The coronal section of brain, in the presence and absence were compared microscopically to determine the toxin induced tissue damage.

Author(s): Janaky Ranjithkumar, B. Prabu and A. J. Vanisree

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