Absorbance correction method for simultaneous determination of OlmesartanMedoxomil and Hydrochlorothiazide in combined tablet dosage form

A new, simple, accurate and sensitive UV-Spectrophotometric absorbance correction method has been developed and validated for simultaneous estimation of Olmesartan Medoxomil (OLME) and Hydrochlorothiazide (HCTZ) in a combined tablet dosage form. Methanol was used as solvent. The wavelengths selected for the absorbance correction method were 256 nm & 318 nm for Olmesartan Medoxomil and Hydrochlorothiazide respectively. The method was found to be linear between the range of 8-28 µg/ml for Olmesartan Medoxomil and 5-30 µg/ml for Hydrochlorothiazide. The mean percentage recovery was found in the range of 100.87% and 100.65% for Olmesartan Medoxomil and Hydrochlorothiazide respectively at three different levels of standard additions. The precision (intra-day, inter-day) of method were found within limits (RSD <2%). Thus the proposed method was simple, precise, economic, rapid and accurate and can be successfully applied for simultaneous determination of Olmesartan Medoxomil and Hydrochlorothiazide in combined tablet dosage form

Author(s): Dharmesh T. Patel and Dipti B. Patel

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