Silica gel supported iodine trichloride and indium triflate were found as efficient and reusable catalysts to the synthesis of a series of xanthenes as potentially interesting biological active molecules in high rates and yields. A broad range of xanthene derivatives were efficiently prepared via a three component reaction between cyclic β-diketones and arylaldehydes (2:1 ratio) with high yield and purity by the use of a catalytic amount of ICl3 /SiO2 and In(CF3 SO3 )3 as Lewis acids under solvent-free and mild conditions. This newly achieved route has some advantage such as facile and simple handling, employing of neat and reusable catalysts, using readily available chemicals, short span of needed time, avoid of employing hazardous solvents, and including green chemistry aspects.
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