A one pot synthesis of 1,3-benzoxazines from schiff’s bases

New Schiff bases (1-6) were prepared and reduced by using NaBH4 to 2-(2-aminoaryl)-methyl phenol; which were refluxed without isolation of reduced product with formaldehyde to afford 1,3-benzoxazines in good yields (13-18). Same series of 1,3-benoxazines were prepared stepwise. Schiff bases were reduced to 2-(2-aminoaryl) methyl phenols (7-12), which were refluxed with formaldehyde in ethanol to give 1,3-benzoxazine.
Author(s): Archana Y. Vibhute, Sainath B. Zangade, Shivaji B. Chavan and Yeshwant B. Vibhute

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