A Facile, Catalyst-free Green Synthesis for Schiff’s Bases in Aqueous Medium under Ultrasonic Irradiation Conditions and Their Antimicrobial Activity

A libraries of Schiff’s base derivatives (12 compounds) such as N'-(substituted- benzylidene)nicotinohydrazides 3(al) were synthesized by reacting nicotinohydrazide (1) with various aryl/heterocyclic aldehydes containing pharmacological active functional groups 2(a-l) under conventional conditions in ethanol as well as ultrasonic conditions in aqueous medium without using any catalyst. It was observed that the reaction in ultrasonic irradiation afforded excellent yields in a simple work-up procedure with in short reaction time and the reaction is an environmentally benign process. The compounds were screened for their antibacterial and antifungal activities at two different concentrations 100, 250 μg/disc as well as minimum inhibitory concentrations against the growth of microbial stains. Most of the synthesized compounds exhibited potential activity against tested microorganisms and low MIC values.

Author(s): Narasaiah. Thalla,a Subba Rao. Devineni,a Brahma Naidu. Parimi,b and Naga Raju. Chamarthia

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