A convenient, green, solvent free synthesis and characterization of novel fluoro chalcones under grind-stone chemistry

A series of (E)-3-[4-(Difluoromethoxy)-3-hydroxyphenyl]-1-phenylprop-2-en-1-ones were synthesized by simple solvent-free grinding technique and conventional method. The effectiveness of synthesis under grinding condition is demonstrated using a broad spectrum of acetophenones with 4-difluoromethoxy-3-hydroxybenzaldedye in presence of base. The synthesized compounds were characterized by FT-IR, LC-MS, 1H NMR, 13C NMR and mass spectra. The HSQC correlation spectrum is analyzed for (E)-3-[4-(Difluoromethoxy)-3-hydroxyphenyl]-1-phenylprop-2-en- 1-one.

Author(s): G. Senthilkumar, K. Neelakandan and H. Manikandan

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