Introduction: Disseminated Talaromyces marneffei is a rare disease caused by conditional pathogen Talaromyces marneffei (T. marneffei) which hazards immunocompromised persons more than healthy ones. Objectives: To report a case of disseminated Talaromyces marneffei in the host with normal immunity. Methods: The patient with cough, fever and cervical lymph nodes enlargement was diagnosed by lymph node biopsy and culture and treated with Amphotericin B and itraconazole. Results: After lymph node biopsy and culture, she was diagnosed with disseminated Talaromyces marneffei and she was cured successfully after treatment with Amphotericin B and itraconazole. Conclusion: Disseminated Talaromyces marneffei involves lung tissue, liver tissue, lymph node and skin, leading to cough and fever.
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