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Abstract

2-Aryldihydrobenzofuran Neolignans: Synthesis of Ficusal and Tomentosanan B

The synthesis of 2-aryldihydrobenzofurans, ficusal and tomentosanan B was achieved via two different cross-coupling methods between aryl or iodoaryl with coniferyl alcohol. Both Pd(OAc)2 catalysed coupling reactions were performed in the presence of base with or without ligand; an oxidant or phase transfer agent. Tomentosanan B was also obtained directly from the reduction of ficusal using NaBH4. The structures of these 2-aryldihydrobenzofuran neolignans were confirmed by 1D and 2D NMR and HRMS.


Author(s): Siti Fadilah Juhan, Siti Mariam Mohd Nor, Nur Kartinee Kassim, Siti Munirah Mohd Faudzi and Mohd Shukri Mat Ali

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Abstracted/Indexed in

  • Chemical Abstracts Service (CAS)
  • Open J Gate
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
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  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
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