Health Science Journal

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TCR Engineering High Impact Factor Journals

Therapy with TCR-engineered T cells is highly potent but reactivity outside tumor needs to be minimized whereas T cell trafficking inside tumor needs to be maximized.

 

T cell target antigens need to show absent expression in a multitude of healthy tissues, including all vital organs.

 

Recognition motif (derived from cognate peptide) of therapeutic TCR needs to be absent from endogenous proteins.

 

Defects in intra-tumoral accumulation of CD8 T cells are categorized according to entry, migration, and local activation of T cells.

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Citations : 12308

Health Science Journal received 12308 citations as per Google Scholar report

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