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We present a vision of clinical science, supported a conceptual framework of intervention development endorsed by the Delaware Project. This framework is grounded in an updated stage model that comes with basic science questions of mechanisms into every stage of clinical science research. The vision presented is meant to unify various aspects of clinical science toward the common goal of developing maximally potent and implementable interventions, while unveiling new avenues of science in which basic and applied goals are of equally high importance. Training in this integrated, translational model may help students learn how to conduct research in every domain of clinical science and at each stage of intervention development. This vision aims to propel the sector to satisfy the general public health goal of manufacturing implementable and effective treatment and prevention interventions.

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